長(zhǎng)春質(zhì)堿、2468-21-5 CAS查詢、長(zhǎng)春質(zhì)堿物化性質(zhì)

發(fā)布時(shí)間:2024-10-18  瀏覽次數(shù):153

 中文名稱： 長(zhǎng)春質(zhì)堿  

 中文別名： 長(zhǎng)春質(zhì)堿;酒石酸長(zhǎng)春質(zhì)堿;瀉花鹼;(+)-長(zhǎng)春堿;瀉花堿;長(zhǎng)春質(zhì)堿(標(biāo)準(zhǔn)品);長(zhǎng)春質(zhì)堿對(duì)照品,;長(zhǎng)春質(zhì)堿, 來(lái)源于長(zhǎng)春花  

 英文名稱： Catharanthine  

 英文別名： (+)-3,4-didehydrocoronaridine;18-beta)-lph;catharanthin;ibogamine-18-carboxylicacid,3,4-didehydro-,methylester,(2-alpha,5-beta,6-a;7-Ethyl-9,10,12,13-tetrahydro-6,9-methano-5H-pyrido[1′,2′:1,2]azepino[4,5-b]indole-6(6aH)-carboxylic acid methyl ester;Catharanthine, 98%, from Catharanthus roseus (L.) G. Don;4-Didehydrocoronaridine;methyl(2-alpha,5-beta,6-alpha,18-beta)-3,4-didehydroibogamine-18-carboxylate  

 CAS號(hào)： 2468-21-5  

 EINECS號(hào)： 219-586-6  

 分子式： C21H24N2O2  

 分子量： 336.43  

 InChI： InChI=1/C21H24N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,10,13,19,22H,3,8-9,11-12H2,1-2H3/t13-,19+,21-/m0/s1  

 分子結(jié)構(gòu)：  

 密度： 1.1367 (rough estimate)  

 熔點(diǎn)： -138-1400C  

 沸點(diǎn)： 472.9°C (rough estimate)  

 閃點(diǎn)： -  

 折射率： 1.6500 (estimate)  

 蒸汽壓： -  

 物化性質(zhì)： 白色結(jié)晶粉末，可溶于甲醇、乙醇、DMSO等有機(jī)溶劑，來(lái)源于長(zhǎng)春花。  

 產(chǎn)品用途： 抑制煙堿受體介導(dǎo)的膈肌收縮,IC50:59.6μM。Catharanthine is a precursor of the anti-tumor drugs vinblastine and vincristine, formed by dimerization of catharanthine with vindoline. Catharanthine itself is an inhibitor of tubulin self-assembly into microtubules, although not so potent as vinblastine or vincristine. Catharanthine also has anticholinergic activity. It showed muscarinic antagonism at 10 microM and fully inhibited nicotinic receptor mediated diaphragm contractions with an IC50 of 59.6 microM.  

 危險(xiǎn)品標(biāo)志： -  

 風(fēng)險(xiǎn)術(shù)語(yǔ)： -  

 安全術(shù)語(yǔ)： -