長春質堿、2468-21-5 CAS查詢、長春質堿物化性質

發布時間:2024-10-18  瀏覽次數:136

 中文名稱： 長春質堿  

 中文別名： 長春質堿;酒石酸長春質堿;瀉花鹼;(+)-長春堿;瀉花堿;長春質堿(標準品);長春質堿對照品,;長春質堿, 來源于長春花  

 英文名稱： Catharanthine  

 英文別名： (+)-3,4-didehydrocoronaridine;18-beta)-lph;catharanthin;ibogamine-18-carboxylicacid,3,4-didehydro-,methylester,(2-alpha,5-beta,6-a;7-Ethyl-9,10,12,13-tetrahydro-6,9-methano-5H-pyrido[1′,2′:1,2]azepino[4,5-b]indole-6(6aH)-carboxylic acid methyl ester;Catharanthine, 98%, from Catharanthus roseus (L.) G. Don;4-Didehydrocoronaridine;methyl(2-alpha,5-beta,6-alpha,18-beta)-3,4-didehydroibogamine-18-carboxylate  

 CAS號： 2468-21-5  

 EINECS號： 219-586-6  

 分子式： C21H24N2O2  

 分子量： 336.43  

 InChI： InChI=1/C21H24N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,10,13,19,22H,3,8-9,11-12H2,1-2H3/t13-,19+,21-/m0/s1  

 分子結構：  

 密度： 1.1367 (rough estimate)  

 熔點： -138-1400C  

 沸點： 472.9°C (rough estimate)  

 閃點： -  

 折射率： 1.6500 (estimate)  

 蒸汽壓： -  

 物化性質： 白色結晶粉末，可溶于甲醇、乙醇、DMSO等有機溶劑，來源于長春花。  

 產品用途： 抑制煙堿受體介導的膈肌收縮,IC50:59.6μM。Catharanthine is a precursor of the anti-tumor drugs vinblastine and vincristine, formed by dimerization of catharanthine with vindoline. Catharanthine itself is an inhibitor of tubulin self-assembly into microtubules, although not so potent as vinblastine or vincristine. Catharanthine also has anticholinergic activity. It showed muscarinic antagonism at 10 microM and fully inhibited nicotinic receptor mediated diaphragm contractions with an IC50 of 59.6 microM.  

 危險品標志： -  

 風險術語： -  

 安全術語： -